Studies on Heterocyclic Enaminonitriles. II. Synthesis and Aromatization of 2-Amino-3-cyano-4,5-dihydrothiophenes

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概要

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• Thirane reacted with malononitrile and sodium hydride to give 2-amino-3-cyano-4,5-dihydrothiophene (IIa) in 57% yield. Similarly, 2-methyl (or 2-phenyl) thirane reacted with malononitrile to form 2-amino-3-cyano-5-methyl (or 4-phenyl)-4,5-dihydrothiophene (IIb or IIc). The reactions of the 2-benzamido (or 2-acetamido) derivatives of (IIa or c) with N-bromosuccinimide (NBS) in the presence of 2,2'-azobisisobutyronitrile gave the corresponding 5-bromothiophenes. On the other hand, the 2-benzamido (or 2-acetamido) derivative of IIb reacted with NBS to yield 2-benzamido (or 2-acetamido)-3-cyano-5-methylthiophene.

• 公益社団法人日本薬学会の論文
• 1982-12-25

著者

• 野田 寛治

  Research Laboratories, Hisamitsu Pharmaceutical Co., Inc.,

• 冨岡 幸彦

  Faculty Of Pharmaceutical Sciences Fukuoka University

• 山方 健司

  Faculty Of Pharmaceutical Sciences Fukuoka University

• 山崎 企善

  Faculty of Pharmaceutical Sciences, Fukuoka University

• 野田 寛治

  Research Laboratories Hisamitsu Pharmaceutical Co. Inc.

• 山崎 企善

  Faculty Of Pharmaceutical Sciences Fukuoka University

• 松田 工

  Research Laboratories, Hisamitu Pharmaceutical Co., Inc.

• 松田 工

  Research Laboratories Hisamitu Pharmaceutical Co. Inc.

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