Studies on Heterocyclic Enaminonitriles. IX. : Ring Openiong of 2-Amino-3-cyano-4,5-dihydrofurans by the Use of Benzoyl(and Acetyl) Chlorides
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概要
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The reaction of 2-amino-3-cyano-4,5-dihydrofuran (Ia) with benzoyl(or acetyl) chloride in the presence of sodium hydride and sodium hydrogen carbonate gave 2-benzoyloxy(or acetoxy)ethyl-malononitrile (IIa or IIIa). Similarly, 2-amino-3-cyano-5-methyl-4,5-dihydrofuran (Ib) and 2-amino-3-cyano-4-phenyl(or 5-phenyl)-4,5-dihydrofuran (Ic or Id) reacted with benzol(or acetyl)-chloride to form the corresponding malononitrile derivatives (IIb-d or IIIb-d). On the other hand, the reaction of Ia with phenacyl bromide gave 3-cyano-2-imino-3-phenacyltetrahydrofuran (IV).
- 公益社団法人日本薬学会の論文
- 1986-02-25
著者
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冨岡 幸彦
Faculty Of Pharmaceutical Sciences Fukuoka University
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山方 健司
Faculty Of Pharmaceutical Sciences Fukuoka University
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山崎 企善
Faculty of Pharmaceutical Sciences, Fukuoka University
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山崎 企善
Faculty Of Pharmaceutical Sciences Fukuoka University
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