Studies on Heterocyclic Enaminonitriles. VI. Synthesis of 2-Amino-3-cyano-4,5-dihydrofurans
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概要
- 論文の詳細を見る
Malononitrile reacts with 2-chloroethanol and 1-chloro-2-propanol (or 2-methyloxirane) in the presence of sodium ethoxide to give 2-amino-3-cyano-4,5-dihydrofuran (Ia) and 2-amino-3-cyano-5-methyl-4,5-dihydrofuran (Ib), respectively. The reaction of malononitrile with 2-phenyl-oxirane or 2-chloro-1-phenylethanol gave 2-amino-3-cyano-4 (and 5)-phenyl-4,5-dihydrofurans (Ic and Id). The 2-benzamido derivatives (IIb-d) of Ib-d were aromatized by treatment with N-bromosuccinimide to give the corresponding furans (IIIb-d).
- 公益社団法人日本薬学会の論文
- 1985-03-25
著者
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冨岡 幸彦
Faculty Of Pharmaceutical Sciences Fukuoka University
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山方 健司
Faculty Of Pharmaceutical Sciences Fukuoka University
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山崎 企善
Faculty of Pharmaceutical Sciences, Fukuoka University
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山崎 企善
Faculty Of Pharmaceutical Sciences Fukuoka University
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松田 工
Research Laboratories, Hisamitu Pharmaceutical Co., Inc.
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松田 工
Research Laboratories Hisamitu Pharmaceutical Co. Inc.
関連論文
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