Studies on Heterocyclic Enaminonitriles. V. Reactions of 2-Amino-3-cyano-1-ethoxycarbonyl-4,5-dihydropyrroles with Acetylenic Esters
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概要
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The reactions of 2-amino-3-cyano-1-ethoxycarbonyl-4,5-dihydropyrrole (Ia) and 2-amino-3-cyano-1-ethoxycarbonyl-5-methyl (or 4-phenyl)-4,5-dihydropyrrole (Ib or Ic) with dimethyl acetylenedicarboxylate and methyl propiolate gave the corresponding 7-amino-4-cyano-1-ethoxycarbonyl-2,3-dihydro-1H-azepines (IIa-c and IIIa-c). On heating with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, IIc and IIIc were converted into dimethyl 6-amino-3-cyano-5-ethoxycarbonylamino-4-phenyl-1,2-benzenedicarboxylate (V) and methyl 6-amino-3-cyano-5-ethoxycarbonylamino-4-phenylbenzenecarboxylate (VI), respectively.
- 社団法人日本薬学会の論文
- 1984-07-25
著者
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松永 尚
Faculty Of Pharmaceutical Sciences Fukuoka University
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園田 美樹
Faculty Of Pharmaceutical Sciences Fukuoka University
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冨岡 幸彦
Faculty Of Pharmaceutical Sciences Fukuoka University
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山崎 企善
Faculty of Pharmaceutical Sciences, Fukuoka University
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山崎 企善
Faculty Of Pharmaceutical Sciences Fukuoka University
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