Studies on Heterocyclic Enaminonitriles. VII. : Reactions of 2-Amino-3-cyano-4,5-dihydrothiophenes with Acetylenic Esters
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概要
- 論文の詳細を見る
The reactions of 2-amino-3-cyano-4,5-dihydrothiophene (Ia) and 2-amino-3-cyano-5-methyl-(or 4-phenyl)-4,5-dihydrothiophene (Ib or Ic) with dimethyl acetylenedicarboxylate (DMAD) or methyl propiolate in dimethyl sulfoxide (DMSO) or hexamethylphosphoric triamide gave the corresponding dimethyl(or methyl) 2-amino-5-cyano-6,7-dihydrothiepin-3,4-dicarboxylate(or 3-carboxylate) (IIa-c or IVa-c). Compounds Ia-c reacted with DMAD in refluxing xylene to give the corresponding dimethyl α-(3-cyano-4,5-dihydro-2-thienylamino)fumarates (IIIa-c).
- 社団法人日本薬学会の論文
- 1986-01-25
著者
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松永 尚
Faculty Of Pharmaceutical Sciences Fukuoka University
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園田 美樹
Faculty Of Pharmaceutical Sciences Fukuoka University
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冨岡 幸彦
Faculty Of Pharmaceutical Sciences Fukuoka University
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山崎 企善
Faculty of Pharmaceutical Sciences, Fukuoka University
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山崎 企善
Faculty Of Pharmaceutical Sciences Fukuoka University
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