Studies on Heterocyclic Enaminonitriles. X. : Synthesis of 4-Amino-7-ethoxycarbonyl-5,6-dihydro-7H-pyrrolo-[2,3-d]pyrimidine-2-acetic Acid Derivatives
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概要
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The reactions of ethyl N-(3-cyano-1-ethoxycarbonyl-4,5-dihydro-1H-2-pyrrolyl)oxamate (IIa) with methyl or ethyl cyanoacetate, α-cyanoacetamide and 1-cyanoacetylpyrrolidine gave the corresponding 4-amino-7-ethoxycarbonyl-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidine-2-acetic acid derivatives (IIIa-1-IIIa-4). Similarly, ethyl N-[3-cyano-1-ethoxycarbonyl-5-methyl(or 4-phenyl)-4,5-dihydro-1H-2-pyrrolyl]oxamate (IIb or IIc) gave the acetic acid derivatives (IIIb-1-IIIb-4 or IIIc-1-IIIc-4) corresponding to IIIa-1-IIIa-4. On acidic hydrolysis, IIIa-c-1 and IIIa-c-2 provided 4-amino-7-ethoxycarbonyl-2-methyl-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidines (IVa-c), which were converted to 4-amino-2-methyl-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidines (Va-c) on alkaline hydrolysis.
- 社団法人日本薬学会の論文
- 1986-02-25
著者
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園田 美樹
Faculty Of Pharmaceutical Sciences Fukuoka University
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冨岡 幸彦
Faculty Of Pharmaceutical Sciences Fukuoka University
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山崎 企善
Faculty of Pharmaceutical Sciences, Fukuoka University
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栗山 伸隆
Faculty of Pharmaceutical Sciences, Fukuoka University
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山崎 企善
Faculty Of Pharmaceutical Sciences Fukuoka University
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栗山 伸隆
Faculty Of Pharmaceutical Sciences Fukuoka University
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