Studies on Heterocyclic Enaminonitriles. IV. Reaction of Ethyl N-(3-Cyano-4,5-dihydro-2-thienyl) oxamates with Cyanomethylene Compounds in the Presence of Triethylamine
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概要
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Ethyl N-(3-cyano-4,5-dihydro-2-thienyl) oxamate (Ia) reacted with ethyl or methyl cyanoacetate, α-cyanoacetamide and 1-cyanoacetylpyrrolidine in the presence of triethylamine to form the corresponding 2-[4-amino-5,6-dihydrothieno [2,3-d] pyrimidine] acetic acid derivatives (IIa-1-IIa-4). Similarly, ethyl N-[3-cyano-5-methyl (or 4-phenyl)-4,5-dihydro-2-thienyl] oxamate (Ib or Ic) gave the corresponding 2-[4-amino-5,6-dihydrothieno-[2,3-d] pyrimidine] acetic acid derivatives (IIb-1-IIb-4 or IIc-1-IIc-4). On acidic hydrolysis, IIa-1,2,IIb-1,2 and IIc-1,2 were converted to 4-amino-2-methyl-5,6-dihydrothieno [2,3-d] pyrimidines (IIIa-c).
- 1983-04-25
著者
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冨岡 幸彦
Faculty Of Pharmaceutical Sciences Fukuoka University
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山崎 企善
Faculty of Pharmaceutical Sciences, Fukuoka University
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小柳 和子
Faculty Of Pharmaceutical Sciences Fukuoka University
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八山 しづ子
Faculty of Pharmaceutical Sciences, Fukuoka University
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山崎 企善
Faculty Of Pharmaceutical Sciences Fukuoka University
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八山 しづ子
Faculty Of Pharmaceutical Sciences Fukuoka University
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