Studies on Tertiary Amine Oxides. LXXX. Reaction of Quinoline 1-Oxide with Phenylacetic Anhydride

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概要

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• Treatment of quinoline 1-oxide (1) with phenylacetic acid and acetic anhydride in boiling benzene for 10 h gave benzaldehyde (2), quinoline (3), 2-benzylquinoline (4), 2-benzoylquinoline (5), phenyl-di (2-quinolyl) carbinol (6), di (2-quinolyl) ketone (7), and N-(2-quinolyl)-2-benzylidene-1,2-dihydroquinoline (8) in small yields. The reaction of 1 with phenylacetic anhydride in boiling benzene for 10 h afforded 1,3-diphenyl-1-(2-quinolyl) acetone (9) and dibenzyl ketone (10) together with small amounts of 2,3,and 5. Further, it was found that phenylacetic anhydride undergoes decarboxylative coupling upon heating with tertiary amines to give 10. The mechanisms of these reactions are discussed.

• 公益社団法人日本薬学会の論文
• 1984-10-25

著者

• 佐伯 清太郎

  Faculty of Pharmaceutical Sciences, Kyushu University

• 舟越 和久

  Faculty of Pharmaceutical Sciences, Kyushu University

• 舟越 和久

  Faculty Of Pharmaceutical Sciences Kyushu University

• 和田 和子

  Faculty Of Pharmaceutical Sciences Kyushu University

• 浜名 政和

  Faculty of Pharmaceutical Sciences, Kyushu University

• 佐伯 清太郎

  Faculty Of Pharmaceutical Sciences Kyushu University

• 浜名 政和

  Faculty Of Pharmaceutical Sciences Kyushu University

• 水岡 雅恵

  Faculty of Pharmaceutical Sciences, Fukuoka University

• 水岡 雅恵

  Faculty Of Pharmaceutical Sciences Kyushu University

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