Studies on Tertiary Amine Oxides. LXXIV. Reactions of Aromatic N-Oxides with 2-Phenyl-2-Thiazolin-4-one in the Presence of Acetic Anhydride
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概要
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Quinoline 1-oxides (1a-e) readily react with 2-phenyl-2-thiazolin-4-one (2) in acetic anhydride at room temperature to afford the corresponding 5-(2-quinolyl) thiazolones (3a-e) in good yields. The reaction of 4-chloroquinoline 1-oxide (1f) gives 4-acetoxy-5-(4-chloro-2-quinolyl)-2-phenylthiazole (4). Hydrolyses of 1a-e with 48% hydrobromic acid under reflux give 2-quinolinemethanethiols as the hydrobromides (6a-e). Similar results were obtained from the reaction of isoquinoline 2-oxide (7), but pyridine 1-oxide was unreactive.
- 公益社団法人日本薬学会の論文
- 1982-06-25
著者
-
佐伯 清太郎
Faculty Of Pharmaceutical Sciences Kyushu University
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浜名 政和
Faculty Of Pharmaceutical Sciences Kyushu University
-
YOUSIF MOHAMMED
Faculty of Pharmaceutical Sciences, Kyushu University
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Yousif Mohammed
Faculty Of Pharmaceutical Sciences Kyushu University:(present Address)chemistry Department Faculty O
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