Synthese von Derivaten der Cinchona-Alkaloide. XXXIII. Synthese von 2'-Cyanoderivaten der Alkaloide der Chinin-Reihe
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概要
- 論文の詳細を見る
Chinin-1'-oxid bzw. Dihydrochinin-1'-oxid ergibt bei der Reissert'schen Reaktion das entsprechende 2'-Cyano-9-O-benzoylderivat des Chinins bzw. Dihydrochinins. Die modifizierte Reissert'sche Reaktion des Dihydrochinin-1'-oxides mit Silbercyanid und Benzoylchlorid in einer Chloroform-Losung ergibt ebenfalls das 2'-Cyano-9-O-benzoyldihydrochinin. Zur Konstitutionsbestimmung des letzerten und zur Kontroll der Reaktion wurde 6-Methoxychinolin-1-oxid der modifizierten Reissert'schen Reaktion unterworfen und 2-Cyano-6-methoxychinolin mit guter Ausbeute erhalten. 2'-Methoxycarbonyl- und 2'-Athoxycarbonyl-derivate des Dihydrochinins wurden hergestellt.
- 公益社団法人日本薬学会の論文
- 1960-06-25
著者
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小林 義郎
Tokyo College of Pharmacy
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金子 主税
Faculty Of Pharmaceutical Sciences Kanazawa University
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浜名 政和
Faculty of Pharmaceutical Sciences, Kyushu University
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落合 英二
ITSUU Laboratory
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浜名 政和
Pharmazeutisches Institut, Universtat Kiusiu
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小林 義郎
Universitat Tokio
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金子 主税
Universitat Tokio
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落合 英二
Pharm. Institut D. Mediz. Fakultat D. Universitat Tokyo
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落合 英二
Faculty Of Pharmaceutical Sciences University Of Tokyo And Research Laboratory Shionogi & Co. Lt
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浜名 政和
Faculty Of Pharmaceutical Sciences Kyushu University
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金子 主税
Pharmaceutical Institute Tohoku University
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