Entstehung von 3-Hydroxyderivaten bei der N-Oxydierung der Chinolinderivate mittels Wasserstoffperoxyds in Eisessig-Losung.

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概要

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• 6-Nitrochinolin ergab bei der Oxydierung mit Wasserstoffperoxyd in einer Eisessig-Losung das entsprechende N-Oxyd nur in einer Ausbeute von 41% und nebenbei entstanden 3-Hydroxy-6-nitrochinolin und sein N-Oxyd in einer Ausbeute von 1% bzw. 27% der Theorie. Die analoge Reaktion mit chinolin-8-carbonsaure bzw. Seinem Athylester ergab kein N-Oxyd sondern das entsprechende 3-Hydroxyderivat in einer Ausbeute von 36% bzw. 21% der Theorie. Die Nebenentstehung von 3-Hydroxyderivat bei der N-Oxydierung eines Chinolinderivates mit Wasserstoffperoxyd in Eisessig-Losung scheint eine allgemeine Erscheinung zu sein, die bei der sterischen oder polarischen Hinderung durch irgendeinen Substituenten deutlicher auftritt.

• 社団法人日本薬学会の論文
• 1960-02-25

著者

• 宮下 修一

  Faculty Of Pharmaceutical Sciences University Of Kanazawa

• 小菅 卓夫

  Shizuoka College Of Pharmacy

• 金子 主税

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 金子 主税

  Pharmaceutical Institute Medical Faculty University Of Tokyo

• 落合 英二

  Pharmazeutische Fakultat, Universitat Tokio

• 島田 巌

  Pharmazeutische Fakultat, Universitat Tokio

• 村田 裕美子

  Pharmazeutische Fakultat, Universitat Tokio

• 小菅 卓夫

  Pharmazeutische Fakultat, Universitat Kanazawa

• 宮下 修一

  Pharmazeutische Fakultat, Universitat Kanazawa

• 川崎 遂志

  Pharmazeutische Fakultat, Universitat Kanazawa

• 落合 英二

  ITSUU Laboratory

• 宮下 修一

  Pharmazeutische Fakultat Universitat Kanazawa

• 落合 英二

  Pharm. Institut D. Mediz. Fakultat D. Universitat Tokyo

• 落合 英二

  Faculty Of Pharmaceutical Sciences University Of Tokyo And Research Laboratory Shionogi & Co. Lt

• 村田 裕美子

  Pharmazeutische Fakultat Universitat Tokio

• 小菅 卓夫

  Pharmazeutische Fakultat Universitat Kanazawa

• 小菅 卓夫

  Pharmaceutical Faculty University Of Kanazawa.

• 金子 主税

  Pharmaceutical Institute Tohoku University

• 川崎 遂志

  Pharmazeutische Fakultat Universitat Kanazawa

• 島田 巌

  Pharmazeutische Fakultat Universitat Tokio

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