A Photochemical Synthesis of 1,2,3,4,5,6-Hexahydro-1-benzazocine-2,6-diones from 4-Hydroxy-2-quinolones

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概要

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• Irradiation of 4-hydroxy-2-quinolones (IVa and IVb) and their enolates in the presence of olefins provided intermolecular 2+2 addition products (V, VII, and VIII). The cycloaddition reactions were shown to be regioselective giving in all cases 1-substituted 1,2,2a, 8b-tetrahydrocyclobuta [c] quinolin-3 (4H)-ones. Base catalyzed retro aldol reaction of these cycloadducts afforded 1,2,3,4,5,6-hexahydro-1-benzazocine-2,6-diones (VI).

• 公益社団法人日本薬学会の論文
• 1980-10-25

著者

• 金子 主税

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 内藤 利彦

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 金子 主税

  Pharmaceutical Institute Tohoku University

• 内藤 利彦

  Faculty Of Pharmaceutical Sciences Kanazawa University

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