A Novel Synthetic Method for Tetronic Acids from 1,3-Dioxin-4-ones via Intra- or Intermolecular Ketene Trapping

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概要

• 論文の詳細を見る

• Novel synthetic routes to tetronic acid and its derivatives from 6-substituted 1,3-dioxin-4-ones through cycloreversion to acylketenes followed by either intra- or intermolecular ketene trapping by a hydroxy function is described. While tetronic acid and its 5-substituted derivatives were synthesized directly from 6-(x-hydroxyalky)-1,3-dioxin-4-ones by intramolecular trapping, 3-acyltetronic acids were prepared by Dieckmann reaction of the β-keto esters obtained from the 6-substituted dioxinones and an approptiate α-hydroxy ester by intermolecdular trapping.

• 社団法人日本薬学会の論文
• 1990-01-25

著者

• 佐藤 雅之

  静岡県立大学薬学部

• 小林 聡

  Pharmaceutical Institute Tohoku University

• 高山 和久

  Pharmaceutical Institute Tohoku University

• 榊 潤一

  Pharmaceutical Institute Tohoku University

• 金子 主税

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 金子 主税

  Pharmaceutical Institute Medical Faculty University Of Tokyo

• 佐藤 雅之

  Pharmaceutical Institute, Tohoku University

• 鈴木 美和子

  Pharmaceutical Institute, Tohoku University

• 鈴木 美和子

  Pharmaceutical Institute Tohoku University

• 金子 主税

  Pharmaceutical Institute Tohoku University

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