Cycloadditions in Syntheses. XXXI. 2+2 Photocycloaddition of 3-Trifluoromethyl Derivatives of Quinoxalin-2(1H)-one and 1,4-Benzoxazin-2-one to Olefins : Effects of the Trifluoromethyl Group(Organic,Chemical)

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概要

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• Irradiation of the title compounds (1 and 2) in the presence of both electron-rich and electron-deficient olefins afforded azetidine derivatives, which were formed by 2+2 cycloaddition of the former compounds to olefins across the carbon-nitrogen double bond. Since quinoxalin-2(1H)-one and 1,4-benzoxazin-2-one and their 3-alkyl derivatives have been known to react only with electron-deficient olefins to give the 2+2 photoadducts, the activation of the carbon-nitrogen double bond in these heteroaromatic systems toward photocycloaddition reactions by the trifluoromethyl group has been demonstrated.

• 社団法人日本薬学会の論文
• 1986-12-25

著者

• 葛西 浩一

  Research And Development Division Kikkoman Corporation

• 金子 主税

  東北大学

• 金子 主税

  Pharmaceutical Institute Medical Faculty University Of Tokyo

• 渡辺 博司

  Pharmaceutical Institute Tohoku University

• 片桐 信弥

  Pharmaceutical Institute, Tohoku University

• 葛西 浩一

  Pharmaceutical Institute, Tohoku University

• 片桐 信弥

  Health Sci. Univ. Hokkaido Hokkaido Jpn

• 片桐 信弥

  Pharmaceutical Institute Tohoku University

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