Synthesis of Carbocyclic Nucleosides from 2-Azabicyclo[2.2.1]hept-5-en-3-ones : Sodium Borohydride-Mediated Carbon : Nitrogen Bond Cleavage of Five- and Six-Membered Lactams
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概要
- 論文の詳細を見る
Various carbocyclic ribofuranosyl nucleosides were stereoselectively synthesized through a small number of steps from 2-azabicyclo[2.2.1]hept-5-en-3-ones by the use of sodium borohydride-mediated C-N bond cleavage as a key step. Ready availability of a novel synthetic precursor, (±)-4β-hydroxymethyl-1β-ureidocyclopentane-2α, 3α-diol [(±)-carbocyclic ribofuranosylurea], provides not only facile routes to carbocyclic robofuranosylpyrimidines, but also another route to the corresponding cyclopentylamine, (±)-1β-amino-4β-hydroxymethylcyclopentane-2α, 3α-diol [(±)-carbocyclic ribofuranosylamine], which is useful for the synthesis of the corresponding purine nucleosides.
- 公益社団法人日本薬学会の論文
- 1991-05-25
著者
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金子 主税
東北大学
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金子 主税
Pharmaceutical Institute Medical Faculty University Of Tokyo
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片桐 信弥
Pharmaceutical Institute, Tohoku University
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野村 昌弘
Pharmaceutical Institute Tohoku University
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武藤 真
Pharmaceutical Institute Tohoku University
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片桐 信弥
Health Sci. Univ. Hokkaido Hokkaido Jpn
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片桐 信弥
Pharmaceutical Institute Tohoku University
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東川 徹
Pharmaceutical Institute, Tohoku University
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東川 徹
Pharmaceutical Institute Tohoku University
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Katagiri N
Pharmaceutical Institute Tohoku University
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