Synthesis of Imidazo[1,5-a]pyrimidines

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概要

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• The synthesis of imidazo[1,5-a]pyrimidines from 2-substituted pyrimidin-4(3H)-ones is described. 2-[(Acylamino)methyl]-6-methylpyrimidin-4-(3H)-ones, prepared by the reaction of β-aminocrotonamide with N-acylated amino acid esters, were treated with POCl_3 to give 2- and 4-chloroimidazo[1,5-a]pyrimidines, which reacted with various nucleophiles to afford 2- and 4-substituted imidazo[1,5-a]pyrimidines.

• 公益社団法人日本薬学会の論文
• 1983-08-25

著者

• 加藤 鐵三

  Central Research Institute Mect Corporation

• 片桐 信弥

  Pharmaceutical Institute, Tohoku University

• 片桐 信弥

  Health Sci. Univ. Hokkaido Hokkaido Jpn

• 片桐 信弥

  Pharmaceutical Institute Tohoku University

• 厚海 修吾

  Pharmaceutical Institute, Tohoku University

• 厚海 修吾

  Structural Biology & Chemistry New Drug Discovery Research Laboratories Tsukuba Research Institu

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