Reaction of 2,2,6-Trimethyl-1,3-dioxin-4-one with Imines

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概要

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• The reaction of 2,2,6-trimethyl-1,3-dioxin-4-one (diketene-acetone adduct) (1) with imines was investigated. Heating of the adduct 1 with N-(1-phenylethylidene) aniline (6a) gave 6-methyl-1,2-diphenyl-4-(1H)-pyridone 7a. Similar treatment of N-benzylideneaniline (3a) gave 3,4-dihydro-6-methyl-2,3-diphenyl-2H-1,3-oxazin-4-one (4a). N-Benzylidenealkylamines likewise reacted with the adduct 1 to give the corresponding 1,3-oxazine derivative 4. Reaction of diketene with N-benzylidenealkylamines in the presence of triethylamine gave the corresponding 1,3-oxazine along with 3-acetyl-1-alkyl-4-phenylazetidin-2-one (8).

• 公益社団法人日本薬学会の論文
• 1983-06-25

著者

• 佐藤 雅之

  静岡県立大学薬学部

• 佐藤 雅之

  Pharmaceutical Institute, Tohoku University

• 加藤 鐵三

  Central Research Institute Mect Corporation

• 加藤 鐵三

  Pharmaceutical Institute. Tohoku University

• 小笠原 弘道

  Pharmaceutical Institute, Tohoku University

• 小笠原 弘道

  Pharmaceutical Institute Tohoku University

• 吉積 絵里子

  Pharmaceutical Institute, Tohoku University, Aobayama

• 吉積 絵里子

  Pharmaceutical Institute Tohoku University Aobayama

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