Synthesis of 1,3-Dioxin-4-ones and Their Use in Synthesis XX. : (6S, 7S, 10R)- and (6R, 7S, 10R)-7-Isopropyl-10-mythyl-4-oxo-1,5-dioxaspiro[5.5]undec-2-enes; Synthesis and Their Use in Enantiomerically Pure Corey Lactone Analogue Synthesis

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概要

• 論文の詳細を見る

• Two chiral spirocyclic dioxinones (S-5 and R-5) useful in teh so-called de Mayo reaction as alternatives to β-diketones (enones) have been synthesized; they not only act as formylacetates (inactive by themselves as enones) but also display remarkable diastereofacial selectivities in photoaddition to alkenes. The sythesis of these dioxinones is described, together with a practicl one-pot synthesis of enantiomerically pure (1S, 4R)-(+)-6-formyl-2-oxabicyclo[3.3.0]oct-6-en-3-one, the key intermediated of prostaglandin synthesis, from the (6S)-spirocyclic dioxinone (S-5).

• 公益社団法人日本薬学会の論文
• 1990-02-25

著者

• 佐藤 雅之

  静岡県立大学薬学部

• 高山 和久

  Pharmaceutical Institute Tohoku University

• 金子 主税

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 金子 主税

  Pharmaceutical Institute Medical Faculty University Of Tokyo

• 佐藤 雅之

  Pharmaceutical Institute, Tohoku University

• 阿部 義人

  Pharmaceutical Institute, Tohoku University

• 古屋 利夫

  Tsukuba Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.,

• 犬飼 紀喜

  Tsukuba Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.,

• 古屋 利夫

  Tsukuba Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

• 金子 主税

  Pharmaceutical Institute Tohoku University

• 阿部 義人

  Pharmaceutical Institute Tohoku University

• 犬飼 紀喜

  Tsukuba Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

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