REDUCTION OF OXIMES OF α-SUBSTITUTED β-KETOESTERS WITH SODIUM CYANOBOROHYDRIDE : STEREOSELECTIVE SYNTHESIS OF 3,4-CIS-SUBSTITUTED AZETIDIN-2-ONES(Communications to the Editor)
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概要
- 論文の詳細を見る
erythro-3-Hydroxyamino-2-alkylbutanoate and its derivatives were prepared stereoselectively by reduction of the oximes of the corresponding β-ketoesters with sodium cyanoborohydride in acidic media. Cyclization of the β-amino acids obtained by reduction and successive hydrolysis gave 3,4-cis-substituted azetidin-2-ones.
- 社団法人日本薬学会の論文
- 1987-11-25
著者
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榊 潤一
Pharmaceutical Institute Tohoku University
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金子 主税
Faculty Of Pharmaceutical Sciences Kanazawa University
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金子 主税
Pharmaceutical Institute Medical Faculty University Of Tokyo
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千葉 卓男
Pharmaceutical Institute, Tohoku University
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石沢 武宣
Pharmaceutical Institute, Tohoku University
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千葉 卓男
Pharmaceutical Institute Tohoku University
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石沢 武宣
Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
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金子 主税
Pharmaceutical Institute Tohoku University
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石沢 武宣
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
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