アミノ酸誘導体に関する研究(第3報)アセトアセチルアミノ酸を用いるトリペプチドおよびテトラペプチドの簡易合成
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概要
- 論文の詳細を見る
N-(4-Bromoacetoacetyl) amino acid esters (2a and 2b), which were easily prepared by bromination of N-acetoacetylamino acid esters (1a and 1b), were treated with hydrogen azide in concentrated sulfuric acid (Schmidt reaction) to give N-(N-bromoacetylglycyl)-amino acid esters (3a and 3b). Treatment of compound 3a and 3b with sodium azide gave the corresponding N-(N-azidoacetylglycyl) amino acid etsers (4a and 4b), which were transformed into tripeptides (5a and 5b) by catalytic hydrogenation in the presence of palladiumcarbon. Similarly, N-(N-acetoacetyl-L-phenylalany)-L-leucine ethyl ester (6) gave rise to tetrapeptide (H-Gly-Gly-Phe-Leu-OEt) (10).
- 社団法人日本薬学会の論文
- 1984-06-25
著者
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榊 潤一
Pharmaceutical Institute Tohoku University
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千葉 卓男
Pharmaceutical Institute, Tohoku University
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榊 潤一
東北大学薬学部
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加藤 鐵三
東北大学薬学部
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千葉 卓男
Pharmaceutical Institute Tohoku University
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加藤 鐵三
Pharmaceutical Institute. Tohoku University
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