Reaction of 2,2-Dimethyl-1,3-dioxin-4-ones with Imines, Carbodiimides, and Isocyanates

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概要

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• The ring transformation of 2,2-dimethyl-1,3-dioxin-4-ones (1) to nitrogen heterocycles was studied. Heating of 1 with imines such as Schiff bases gave rise to [2+4] cycloadducts of imines to acylketenes (2), i.e., 3,4-dihydro-1,3-oxazin-4-one derivatives (4). Similarly, 1 reacted with carbodiimides to yield 2-imino-1,3-oxazin-4-one derivatives (11 and 12). The reaction of 1 with phenyl isocyanate gave 3-phenyl-1,3-oxazine-2,4-diones (15), while the reaction with 2-pyridyl isocyanate gave pyrido [1,2-a] pyrimidin-4-one derivatives (18).

• 公益社団法人日本薬学会の論文
• 1984-07-25

著者

• 佐藤 雅之

  静岡県立大学薬学部

• 佐藤 雅之

  Pharmaceutical Institute, Tohoku University

• 加藤 鐵三

  Central Research Institute Mect Corporation

• 加藤 鐵三

  Pharmaceutical Institute. Tohoku University

• 小笠原 弘道

  Pharmaceutical Institute, Tohoku University

• 小笠原 弘道

  Pharmaceutical Institute Tohoku University

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