Studies on Ketene and Its Derivatives. XXXI. 2-Acetonyloxazolines
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概要
- 論文の詳細を見る
N-Allylacetoacetamide (III) was heated in conc. H_2SO_4 to give 2-acetonyl-5-methyl-2-oxazoline (IVb). Acidic hydrolysis of IVb afforded isopropanolamine, acetone and carbon dioxide. N-(β-Hydroxyalkyl) acetoacetamide (X) was heated under reflux with thionyl chloride in chloroform to give N-(β-chloroalkyl) acetoacetamide (XI). Treatment of XI with methanolic KOH gave 2-acetonyl-2-oxazoline (IV). When the reaction of X with thionyl chloride was carried out at room temperature, 2,3,4,5-tetrahydro-1,4-oxazepin-5-one (XII) was obtained.
- 公益社団法人日本薬学会の論文
- 1969-12-25
著者
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佐藤 雅之
Pharmaceutical Institute, Tohoku University
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加藤 鉄三
Pharmaceutical Institute Tohoku University
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加藤 鉄三
Pharmaceutical Institute. Tohoku University
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