Synthesis of Methylpyridine Derivatives (XXI). Amination of Chloro-2,6-lutidines and Their N-Oxides via a Hetaryne Mechanism
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概要
- 論文の詳細を見る
Reactions of chloro-2,6-lutidines and their N-oxides with liquid ammonia in the presence of potassium amide proceed via a hetaryne mechanism to give 3-and 4-amino compounds. Amination of 3- as well as 4-chloro-2,6-lutidine affords 3-amino-2,6-lutidine as the main product (13〜15%) with a small amount of the 4-amino isomer. In the case of amination of their N-oxides, mole ratio of the resulting amino isomers is reverse to that in the case of chlorolutidines. 3-Chloro-2,6-lutidine 1-oxide forms 4-amino-2,6-lutidine 1-oxide as the main product (50%) with the 3-amino isomer as a by-product (13%), and reaction of 4-chloro-2,6-lutidine 1-oxide gives 4-amino compound (34%) and the 3-amino isomer (6.5%).
- 公益社団法人日本薬学会の論文
- 1965-08-25
著者
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加藤 鉄三
Pharmaceutical Institute Tohoku University
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新妻 卓逸
東北大学薬学部
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新妻 卓逸
Pharmaceutical Institute, Tohoku University School of Medicine
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