Methylpyridine誘導体の合成(第26報)3-Acylamido-4-chloro-2,6-lutidineの液体アンモニア中カリウムアミドによる閉環反応
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概要
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Reaction of 3-acylamido-4-chloro-2,6-lutidine (Ia-d) with KNH_2 in liq. NH_3 was carried out and 3-acetamido-(Ia) and 3-benzamido-4-chloro-2,6-lutidine (Ib) were converted into the oxazolopyridine derivatives (II and V) and 3-acylamido-4-amino-2,6-lutidine (III and VI), respectively. Similar reaction of 3-phenylacetamido-(Ic) and 3-acetoacetamido-4-chloro-2,6-lutidine (Id) gave the oxazolopyridine derivatives (VII and XIV) and the pyrrolinopyridine derivatives (VIII and XV), respectively. Acylation of VIII afforded 6-acetyl derivatives (X), and methylation of VIII with methyl iodide gave 1,3,5,7-tetramethyl derivatives (IX). Catalytic reduction of XV with platinum afforded 3-ethyl-3-hydroxy derivatives (XVIII).
- 公益社団法人日本薬学会の論文
- 1972-08-25
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