キノリン誘導体の塩素化反応
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概要
- 論文の詳細を見る
4-Methylquinoline, when treated with chlorine in carbon tetrachloride, undergoes addition reaction to give 5,6,7,8,8-pentachloro-5,6,7,8-tetrahydro-4-methylquinoline. Similarly, 2-chloro-4-methylquinoline and 4-chloro-2-methylquinoline undergo addition reaction to give 2,5,6,7,8-pentachloro-5,6,7,8-tetrahydro-4-methylquinoline and 4,5,6,7,8,8-hexachloro-5,6,7,8-tetrahydro-2-methylquinoline, respectively. On the other hand, similar chlorination of 2-ethoxy-4-methylquinoline gives 6,8-dichloro-2-ethoxy-4-methylquinoline and 3,6-dichloro-4-methylcarbostyril. Ch1orination of 2-chloroquinoline gives 2,5,6,7,8-pentachloro-5,6,7,8-tetrahydroquinoline but that of 4-chloroquinoline or quinoline gives mainly 3,4,6,8-tetrachloroquinoline.
- 公益社団法人日本薬学会の論文
- 1973-01-25
著者
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山中 宏
東北大学薬学部
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加藤 鉄三
東北大学 薬
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加藤 鉄三
東北大学薬学部
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清水 猛
Pharmaceutical Institute, Tohoku University
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清水 猛
Pharmaceutical Institute Tohoku University
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清水 猛
東北大学薬学部
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加藤 鉄三
Pharmaceutical Institute. Tohoku University
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