Keteneおよびその誘導体の研究(第27報) : β-Aminocrotonamideのアシル化および閉環反応
スポンサーリンク
概要
- 論文の詳細を見る
Reaction of β-aminocrotonamide (I) with monoch1oroacetic anhydride affords β-(monochloroacetamido)crotonamide (IIa), which on heating in tetralin changes into 2-chloromethyl-6-methyl-4(3H)-pyrimidinone(IIIa). Reduction of IIIa gives 2,6-dimethyl-4(3H)-pyrimidinone (VII). Similarly, 2-dichloromethyl-6-methyl-4(3H)-pyrimidinone (IIIb) and 2-trichloromethyl-6-methyl-4(3H)-pyrimidinone (IIIc) are obtained from β-(dichloroacetamido)crotonamide (IIb) and β-(trichloroacetamido)crotonamide (IIc) by a similar treatment as above. The reaction of cyanoacetyl chloride with β-aminocrotonamide (I) affords β-(cyanoacetamido)crotonamide (IId), which, however, dose not change into 2-cyanomethyl-6-methyl-4(3H)-pyrimidinone (IIId).
- 公益社団法人日本薬学会の論文
- 1969-04-25
著者
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加藤 鉄三
東北大学医学部薬学科
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山中 宏
東北大学医学部薬学科
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加藤 鉄三
Pharmaceutical Institute. Tohoku University
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川又 淳司
Pharmaceutical Institute Tohoku University
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川又 淳司
東北大学医学部薬学科
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