Keteneおよびその誘導体の研究(第45報) : 2-Alkyl-2-imidazolineとDiketeneとの反応
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概要
- 論文の詳細を見る
Reaction of 2-methyl-(Ia), 2-ethyl-(Ib), and 2-benzyl-2-imidazoline (Ic) with diketene in acetone gave 8-substituted 7-hydroxy-7-methyl-5-oxo-2,3,5,6,7,8-hexahydroimidazo[1,2-α]-pyridine derivatives (8-substituent=H (IIa), CH_3 (IIb), C_6H_5 (IIc)). Treatment of II with conc. H_2SO_4. afforded 8-substituted 7-methyl-5-oxo-2,3-dihydro-1H-imidazo[1,2-α]-pyridine derivatives (IIIa, b, c). Each II and III reacted with acetic anhydride to give 8-substituted 1-acetyl-7-methyl-5-oxo-2,3-dihydro-1H-imidazo[1,2-α]pyridine derivatives (IVa, b, c). Acetylation of I with ketene in chloroform afforded N-acetates (Va, b, c), which reacted with diketene in acetic acid to give IV and VI.
- 公益社団法人日本薬学会の論文
- 1971-11-25
著者
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坂本 尚夫
Pharmaceutical Institute, Tohoku University
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加藤 鉄三
東北大学 薬
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加藤 鉄三
東北大学医学部薬学科
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坂本 尚夫
東北大学医学部薬学科
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加藤 鉄三
Pharmaceutical Institute. Tohoku University
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坂本 尚夫
Pharmaceutical Institute Tohoku University
関連論文
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