Studies on Pyrimidine Derivatives. XII. Reaction of 4,6-Disubstituted Pyrimidine N-Oxides with Dimethyl Acetylenedicarboxylate
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概要
- 論文の詳細を見る
The 1,3-dipolar cycloaddition of 4-benzyloxy-6-methylpyrimidine 1-oxide (Ia) with dimethyl acetylenedicarboxylate (DMAD) gave dimethyl α-oxo-α'-(4-benzyloxy-6-methyl-2-pyrimidinyl) succinate (IIa), which was readily hydrolyzed to methyl 4-benzyloxy-6-methyl-2-pyrimidineacetate (IIIa). A similar reaction of 4-methoxy-(Ib) and 4-ethoxy-6-methylpyrimidine 1-oxide (Ic) gave corresponding methyl 2-pyrimidineacetates (IIIb, c). On the other hand, 6-methyl-4-piperidinopyrimidine 1-oxide (Id) reacted with DMAD to give a betaine derivative, 1-(6-methyl-4-piperidino-1-pyrimidinio)-1,2-bis (methoxycarbonyl) ethenyl-2-oxide (IV).
- 公益社団法人日本薬学会の論文
- 1979-10-25
著者
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水柿 道直
Pharmaceutical Institute Tohoku University
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坂本 尚夫
Pharmaceutical Institute, Tohoku University
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山中 宏
Pharmaceutical Institute, Tohoku University
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新妻 節子
Pharmaceutical Institute, Tohoku University
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坂本 尚夫
Pharmaceutical Institute Tohoku University
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新妻 節子
Pharmaceutical Institute Tohoku University
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