Studies on the Metabolism of Unsaturated Fatty Acids. V. Isomerization of Thiol Esters of cis-2-Alkenoic Acids during Their Preparation and Alkaline Hydrolysis

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概要

• 論文の詳細を見る

• N-Acetylcysteamine and coenzyme A esters of cis-2-alkenoic acids have been found to undergo isomerization to the corresponding trans-isomers during their preparation by the mixed anhydride method and also during their alkaline hydrolysis. The isomerization might proceed by interaction of the free thiol group and the cis-double bond of 2-alkenoic thiol esters. The use of pyridine as a base and three or more equivalents of the mixed anhydride to the thiol compound prevented the formation of the trans-isomer. Addition of hydrogen peroxide during alkaline hydrolysis also prevented the isomerization completely.

• 公益社団法人日本薬学会の論文
• 1982-01-25

著者

• 水柿 道直

  Pharmaceutical Institute Tohoku University

• 山中 宏

  Pharmaceutical Institute, Tohoku University

• 白石 隆幸

  Pharmaceutical Institute, Tohoku University

• 伊藤 葉子

  Pharmaceutical Institute, Tohoku University

• 星野 敏明

  Pharmaceutical Institute, Tohoku University

• 伊藤 葉子

  Pharmaceutical Institute Tohoku University

• 白石 隆幸

  Laboratory Of Health Chemistry Niigata College Of Pharmacy

• 星野 敏明

  Pharmaceutical Institute Tohoku University

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