Antivertigo Agents. IV. Synthesis and Antivertigo Activity of 6-[ω-(4-Aryl-1-piperazinyl) alkyl]-5,6,7,8-tetrahydro-1,6-naphthyridines
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概要
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A series of novel 6-[ω-(4-aryl-1-piperazinyl) alkyl]-5,6,7,8-tetrahydro-1,6-naphthyridines was synthesized and evaluated for antivertigo activity by testing their ability to inhibit spontaneous nystagmus in cats. Structure-activity relationships are discussed. Many of the compounds having the 4-(2-alkoxyphenyl) piperazine group as the 4-arylpiperazine moiety showed more potent antivertigo activity than diphenidol. Among them, 2-{2-[4-(2-ethoxyphenyl)-1-piperazinyl] ethyl}-1,2,3,4,6,7,8,9-octahydrobenzo [b] [1,6] naphthyridine (NK 422,41) was selected as a promising antivertigo agent. NK 422 also exhibited a more potent inhibitory effect on apomorphine-induced vomiting in dogs than diphenidol.
- 社団法人日本薬学会の論文
- 1984-10-25
著者
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坂本 尚夫
Pharmaceutical Institute, Tohoku University
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山中 宏
Pharmaceutical Institute, Tohoku University
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宮崎 寛
Research Laboratories Of Pharmaceutical Division Nippon Kayaku Co.
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塩沢 明
日本化薬
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塩沢 明
Research Laboratories of Pharmaceutical Division, Nippon Kayaku Co.
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市川 裕一郎
Research Laboratories of Pharmaceutical Division, Nippon Kayaku Co.
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小室 主税
Research Laboratories of Pharmaceutical Division, Nippon Kayaku Co.
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石川 道雄
Research Laboratories of Pharmaceutical Division, Nippon Kayaku Co.
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古田 康彦
Research Laboratories of Pharmaceutical Division, Nippon Kayaku Co.
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蔵重 修二
Research Laboratories of Pharmaceutical Division, Nippon Kayaku Co.
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市川 裕一郎
Faculty of Pharmaceutical Sciences, Chiba University
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石川 道雄
Research Laboratories Of Pharmaceutical Division Nippon Kayaku Co.
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坂本 尚夫
東北大院薬
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坂本 尚夫
Pharmaceutical Institute Tohoku University
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小室 主税
Research Laboratories Of Pharmaceutical Division Nippon Kayaku Co.
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坂本 尚夫
東北大学大学院薬学研究科
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古田 康彦
Research Laboratories Of Pharmaceutical Division Nippon Kayaku Co.
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市川 裕一郎
Faculty Of Pharmaceutical Sciences Chiba University
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蔵重 修二
Research Laboratories of Pharmaceuticals Group, Nippon Kayaku CO., Ltd.,
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