Condensed Heteroaromatic Ring Systems. IX. : Total Synthesis of Aaptamine

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概要

• 論文の詳細を見る

• A five-step synthesis of aaptamine, a marine alkaloid containing a benzo[d, e][1,6]naphthyridine ring, from 6,7-dimethoxy-8-nitro-1(2H)-isoquinolone was accomplished in satisfactory yield. As a basis for the above synthesis, a facile preparation of 6,7-dimethozy-1(2H)-isoquinolones from 3,4-dimethoxybenzaldehydes was developed using the palladium-catalyzed reaction of o-bromobenzaldehyde derivatives with trimethylsilylacetylene as a key reaction.

• 公益社団法人日本薬学会の論文
• 1986-07-25

著者

• 根東 義則

  Pharmaceutical Institute, Tohoku University

• 坂本 尚夫

  Pharmaceutical Institute, Tohoku University

• 山中 宏

  Pharmaceutical Institute, Tohoku University

• 三浦 紀生

  Pharmaceutical Institute Tohoku University

• 根東 義則

  Graduate School Of Pharmaceutical Sciences Tohoku University

• 坂本 尚夫

  東北大院薬

• 坂本 尚夫

  Pharmaceutical Institute Tohoku University

• 坂本 尚夫

  東北大学大学院薬学研究科

関連論文

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