Studies on Quinoline and Isoquinoline Derivatives. IX. Synthesis of Pyrrolo [1,2-b] isoquinolines from 3-Bromoisoquinoline Derivatives
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概要
- 論文の詳細を見る
The reaction of 3-bromo-1-methoxyisoquinoline with propargyl alcohol in the presence of dichlorobis (triphenylphosphine) palladium and cuprous iodide gave 3-(1-methoxy-3-isoquinolyl) propargyl alcohol in good yield. Cyclization of 3-(1-methoxy-3-isoquinolyl) propanol obtained by the catalytic reduction of the propargyl alcohol, afforded a 1,2,3,5-tetrahydropyrrolo [1,2-b] isoquinoline derivative. The synthesis of a pyrrolo [3,2,1-de] phenanthridine derivative was accomplished by the introduction of an acrylic acid moiety into the pyrrolo [1,2-b] isoquinoline and subsequent reduction and cyclization of the resulting ethyl pyrrolo [1,2-b] isoquinoline-10-acrylate.
- 公益社団法人日本薬学会の論文
- 1983-07-25
著者
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山中 宏
Pharmaceutical Institute, Tohoku University
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白岩 雅文
Pharmaceutical Institute, Tohoku University
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坂本 尚夫
Pharmaceutical Institute Tohoku University
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白岩 雅文
Pharmaceutical Institute Tohoku University
関連論文
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