Studies on Pyrimidine Derivatives. VI. On the Reactivity of the 2-Methyl Group of 1,2,4-Trimethyl-6-oxo-1,6-dihydropyrimidine

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概要

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• While nitrosation of 6-substituted 2,4-dimethylpyrimidines with ethyl nitrite in liquid ammonia occurred preferentially at the 4-methyl group to give the corresponding pyrimidine-4-aldoximes, the same reaction of 1,2,4-trimethyl-6-oxo-1,6-dihydropyrimidine (IV) afforded 1,4-dimethyl-6-oxo-1,6-dihydropyrimidine-2-aldoxime. Acylation of IV with ethyl benzoate and diethyl oxalate under basic conditions also gave α-(1,4-dimethyl-6-oxo-1,6-dihydro-2-pyrimidinyl) acetophenone and ethyl 3-(1,4-dimethyl-6-oxo-1,6-dihydro-2-pyrimidinyl) pyruvate, respectively.

• 公益社団法人日本薬学会の論文
• 1978-03-25

著者

• 山中 宏

  Pharmaceutical Institute, Tohoku University

• 阿部 弘之

  Pharmaceutical Institute Tohoku University

• 坂本 尚夫

  Pharmaceutical Institute Tohoku University

• 平沼 英敏

  Pharmaceutical Institute Tohoku University

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