Studies on as-Triazine Derivatives. XII. : Synthesis of Alkenyl-1,2,4-triazine Derivatives

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概要

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• 3-Methyl-5,6-diphenyl-1,2,4-triazne (1) was treated with chlorine to give 3-trichloromethyl-5,6-diphenyl-1,2,4-triazine (2) as a sole product. On treatment with an excess (4.5 mol eq) of triphenylphosphine, 2 was transformed into α-(5,6-diphenyl-1,2,4-triazin-3-yl)methylenetriphenyl-phosphorane (3) in improved yield. The condensation of 3 with various aldehydes afforded 3-alkenyl-5,6-diphenyl-1,2,4-triazines (6).The application of this method to the 5-position and 6-position of 1,2,4-triazine was also investigated.

• 公益社団法人日本薬学会の論文
• 1988-05-25

著者

• 山中 宏

  Pharmaceutical Institute, Tohoku University

• 今野 昌悦

  東北大学薬学部

• 今野 昌悦

  Pharmaceutical Institute, Tohoku University

• 藤村 聡

  Pharmaceutical Institute Tohoku University

• 鷺 又市

  東北大学薬学部

• 林 一彦

  Pharmaceutical Institute Tohoku University

• 鷺 又市

  Pharmaceutical Institute, Tohoku University

• 高春 悦子

  Pharmaceutical Institute, Tohoku University

• 高春 悦子

  Pharmaceutical Institute Tohoku University

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