Hydration and Hydrogenation of Acetylenic Side-Chains at the 4- or 5-Position of Isoxazoles
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概要
- 論文の詳細を見る
Hydration of 5-isoxazolyl-phenyl (or -butyl) acetylenes (1a, b) in dilute sulfuric acid in the presence of mercuric sulfate afforded 5-isoxazolylmethyl phenyl (or butyl) ketones (3a, b), predominantly. In contrast, the hydration of 4-isoxazolyl-phenyl (or -butyl)-acetylenes (2a-d) under identical conditions gave 4-isoxazolyl benzyl (or pentyl) ketones (5a-d) as the main products. The structure of one of these products, 3,5-dimethyl-4-isoxazolyl benzyl ketone (5a), was determined by Beckmann rearrangement. Isoxazoles containing a cis-alkene or alkane chain were obtained by the catalytic reduction of the above acetylenes without cleaving the isoxazole nucleus.
- 公益社団法人日本薬学会の論文
- 1981-12-25
著者
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坂本 尚夫
Pharmaceutical Institute, Tohoku University
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山中 宏
Pharmaceutical Institute, Tohoku University
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今野 昌悦
東北大学薬学部
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白岩 雅文
Pharmaceutical Institute, Tohoku University
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今野 昌悦
Pharmaceutical Institute, Tohoku University
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坂本 尚夫
Pharmaceutical Institute Tohoku University
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白岩 雅文
Pharmaceutical Institute Tohoku University
関連論文
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- Studies on Pyrimidine Derivatives. X. Coupling Reaction of 5-Halopyrimidines with Olefinic Compounds in the Presence of Palladium Acetate and Triphenylphosphine
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