Condensed Heteroaromatic Ring Systems. V. : Formal Synthesis of Matrine and Related Compounds Using Palladium-Catalyzed Carbon-Carbon Bond Formations as Key Reactions

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概要

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• The iodination and subsequent dehydroxychlorination of 1,6-naphthyridin-5(6H)-one gave 5-chloro-8-iodo-1,6-naphthyridine, which was converted to the 5-methyoxy derivative. Starting from this compound, didehydromatrine was synthesized by using palladium-catalyzed cross-coupling reactions with ethyl acrylate and 3-butyn-1-ol, as key reactions. Similarly, nordehydro-α-matrinidine was synthesized through four steps from 8-bromo-1,6-naphthyridine, obtained by the bromination o unsubstituted 1,6-naphthyridine.

• 公益社団法人日本薬学会の論文
• 1986-05-25

著者

• 根東 義則

  Pharmaceutical Institute, Tohoku University

• 坂本 尚夫

  Pharmaceutical Institute, Tohoku University

• 山中 宏

  Pharmaceutical Institute, Tohoku University

• 三浦 紀生

  Pharmaceutical Institute Tohoku University

• 坂本 尚夫

  東北大院薬

• 坂本 尚夫

  Pharmaceutical Institute Tohoku University

• 坂本 尚夫

  東北大学大学院薬学研究科

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