Studies on Pyrimidine Derivatives. VIII. Ring-Cleavage Reaction of 4,6-Dimethylpyrimidine 1-Oxide
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概要
- 論文の詳細を見る
Unlike quinoline and isoquinoline N-oxides, 4,6-dimethylpyrimidine 1-oxide reacted with active methylene compounds such as malononitrile, ethyl cyanoacetate, and ethyl ethoxycarbonylacetimidate to give ring-opened products. In these cases, none of pyrimidine derivatives with a substituent at the 2-position were isolated. On the other hand, the pyrimidine 1-oxide was condensed with 5-amino-3-methyl-isoxazole to give 2-(5-amino-3-methyl-4-isoxazolyl)-4,6-dimethylpyrimidine. Comparing these two reactions, the driving force of the ring-fission of the reaction intermediates was discussed.
- 公益社団法人日本薬学会の論文
- 1978-11-25
著者
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小川 茂
Pharmaceutical Institute Tohoku University
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坂本 尚夫
Pharmaceutical Institute, Tohoku University
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山中 宏
Pharmaceutical Institute, Tohoku University
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坂内 由美
Pharmaceutical Institute, Tohoku University
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坂本 尚夫
Pharmaceutical Institute Tohoku University
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坂内 由美
Pharmaceutical Institute Tohoku University
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