Studies on Pyrimidine Derivatives. XXXIV. Substituent Effect on the Reaction of 4-Substituted 2,6-Dimethylpyrimidine 1-Oxides with Acetic Anhydride
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概要
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The reaction of 2-methyl-and 4-methylpyrimidine N-oxides with acetic anhydride proceeded smoothly in benzene solution to give 2-acetoxymethyl- and 4-acetoxymethylpyrimidines, respectively. The same reaction of 4-methoxy-2,6-dimethylpyrimidine 1-oxide afforded 2-acetoxymethyl-4-methoxy-6-methylpyrimidine as a sole product. Other examples of such siteselective acetoxylation of pyrimidine N-oxides are also described.
- 公益社団法人日本薬学会の論文
- 1984-02-25
著者
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山中 宏
Pharmaceutical Institute, Tohoku University
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吉澤 博
Pharmaceutical Institute, Tohoku University
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坂本 尚夫
Pharmaceutical Institute Tohoku University
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吉澤 博
Pharmaceutical Institute Tohoku University
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金田 宗一
Pharmaceutical Institute, Tohoku University
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金田 宗一
Pharmaceutical Institute Tohoku University
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