Studies on Pyrimidine Derivatives. XVIII. Reaction of Active Methyl Groups on Pyrimidine N-Oxides
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概要
- 論文の詳細を見る
Knoevenagel-type condensation and the Mannich reaction were investigated with various pyridine N-oxides having an active methyl group. For example, 6-methyl-4-phenylpyrimidine 1-oxide (Va) readily reacted with benzaldehyde in an aqueous ethanolic solution of potassium hydroxide, while 4-methyl-6-phenylpyrimidine (IVa) failed to react with benzaldehyde under the same conditions. When Va was treated with piperidine hydrochloride and paraformaldehyde, bis piperidinomethylation occurred at the 6-methyl group. The product was transformed into 4-phenyl-6-(2-piperidinoethyl) pyrimidine 1-oxide (XXIIa) by treatment with 5% sulfuric acid at 90°.
- 公益社団法人日本薬学会の論文
- 1980-05-25
著者
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小川 茂
Pharmaceutical Institute Tohoku University
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山中 宏
Pharmaceutical Institute, Tohoku University
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今野 昌悦
東北大学薬学部
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今野 昌悦
Pharmaceutical Institute, Tohoku University
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