Condensed Heteroaromatic Ring Systems. VI. : Synthesis of Indoles and Pyroolopyridines from o-Nitroarylacetylenes
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概要
- 論文の詳細を見る
Catalytic hydrogenation of o-nitrophenylacetaldehyde diethyl acetal over palladium-carbon, followed by intramolecular cyclization of the resulting o-aminophenylacetaldehyde diethyl acetal with hydrochloric acid, gave indole. Similarly, 4-methylindole, ethyl 5-indolecarboxylate, and various pyrrolopyridines were synthesized from the corresponding o-nitroacrylacetaldehyde derivatives. The preparation of the desired o-nitroarylacetaldehydes was accomplished by the condensation of o-halonitroaromatics with trimethylsilylacetylene in the presence of dichloro-bis(triphenylphosphine)palladium as a catalyst, followed by ethanolysis of the resulting o-(tri-methylsilylethynyl)nitroaromatics.
- 公益社団法人日本薬学会の論文
- 1986-06-25
著者
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根東 義則
Pharmaceutical Institute, Tohoku University
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山中 宏
Pharmaceutical Institute, Tohoku University
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坂本 尚夫
東北大院薬
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坂本 尚夫
Pharmaceutical Institute Tohoku University
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坂本 尚夫
東北大学大学院薬学研究科
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