Reductive Amination of Ethynylpyridines with Sodium Cyanoborohydride

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概要

• 論文の詳細を見る

• In order to investigate the structure-activity relationship of betahistine derivatives, a general synthesis of methylated 2-(2-methylaminoethyl) pyridines was developed based on the addition of methylamine hydrochloride to methylated 2-ethynylpyridines under reductive conditions. In addition, the scope and limitations of the reductive addition were briefly examined. For example, the reaction proceeded smoothly with p-nitrophenylacetylene, whereas phenylacetylene itself did not react with methylamine.

• 公益社団法人日本薬学会の論文
• 1984-12-25

著者

• 根東 義則

  Pharmaceutical Institute, Tohoku University

• 坂本 尚夫

  Pharmaceutical Institute, Tohoku University

• 山中 宏

  Pharmaceutical Institute, Tohoku University

• 佐藤 香

  Pharmaceutical Institute Tohoku University

• 坂本 尚夫

  東北大院薬

• 永田 英夫

  Pharmaceutical Institute Tohoku University

• 坂本 尚夫

  Pharmaceutical Institute Tohoku University

• 坂本 尚夫

  東北大学大学院薬学研究科

関連論文

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