Studies on Ketene and Its Derivatives. LXXV. Reaction of Diketene with N-Benzylacetimidate and Lactim Ethers to give 1,6-Naphthyridine Derivatives
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概要
- 論文の詳細を見る
Reaction of diketene with ethyl N-benzylacetimidate (Ia) in acetic acid gave 3-acetyl-1,6-dibenzyl-4,7-dimethyl-1H, 6H-1,6-naphthyridine-2,5-dione (IIa) in 51% yield. Similarly lactim ethers such as 2-methoxy-1-pyrroline (Ib), 2-methoxy-3,4,5,6-tetrahydropyridine (Ic), and 2-methoxy-3,4,5,6-tetrahydro-7H-azepine (Id) gave the corresponding 5-acetyl-6-methyl-4,7-dioxo-1,2,10,11-tetrahydro-4H, 7H, 9H-dipyrrolo[1,2-g : 3', 2', 1'-tj]-1,6-naphthyridine (IIb) (35%), 6-acetyl-7-methyl-5,8-dioxo-2,3,10,11,12,13-hexahydro-1H, 5H, 8H-quinolizino[1,9-ab]quinolizine (IIc) (66%), and 7-acetyl-8-methyl-6,9-dioxo-1,2,3,4,12,13,14,15-octahydro-6H, 9H, 11H-bisazepino[1,2-g : 3', 2', 1'-tj]-1,6-naphthyridine (IId) (40%). Treatment of IIa-d with KOH in EtOH resulted in the formation of the deacetylated derivatives IIIa-d.
- 社団法人日本薬学会の論文
- 1975-11-25
著者
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坂本 尚夫
Pharmaceutical Institute, Tohoku University
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加藤 鉄三
東北大学 薬
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加藤 鉄三
Pharmaceutical Institute Tohoku University
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加藤 鉄三
Pharmaceutical Institute. Tohoku University
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坂本 尚夫
Pharmaceutical Institute Tohoku University
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