ケテンおよびその誘導体の研究(第104報)3-アミノクロトンアミド誘導体とジケテンとの反応

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3-Benzylamino- and 3-morpholinocrotonamide (8 and 9) reacted with diketene to give the corresponding 6-methyl-2-pyridone derivatives (23 and 24), respectively. The reaction of N-methyl-3-morpholinocrotonamide (11) and N-benzyl-3-benzylaminocrotonamide (12) with diketene afforded the corresponding pyrano [3,2-c] pyridine-2,5-dione derivatives (27 and 28). The reaction of N-benzyl-3-morpholinocrotonamide (13) with diketene gave 8-acetyl-6-benzyl-6,7-dihydro-2,5-dimethyl-4H-pyrano [3,2-c] pyridine-4,7-dione (29). On the other hand, 3-aminocrotonanilide derivatives (14-19) reacted with diketene to give 2-pyridones (30,32,35,37,39) and 4-pyridones (34,36,38,40). The reaction of 3-morpholinocrotonanilides (20-22) with diketene to give the corresponding 3-carbamoyl-4-pyrone derivatives (41-43) is also described.
社団法人日本薬学会の論文
1981-01-25