Reaction of Ethyl 4-Bromoacetoacetate with Carbon Disulfide and Active Methylene Compounds
スポンサーリンク
概要
- 論文の詳細を見る
Reaction of ethyl 4-bromoacetoacetate (1) with 2-cyanoethene-1,1-dithiol derivatives (prepared from carbon disulfide and active methylene compounds such as ethyl cyanoacetate and malononitrile in the presence of sodium hydride) gave 2-substituted 4-hydroxy-1,3-dithiolane-4-acetates, 2a and 2b. On the other hand, reaction of 1 with 2-cyano-1-methylthioethene-1-thiol derivatives (prepared from 2-cyanoethene-1,1-dithiol derivatives and methyl iodide) gave 4-substituted 3-amino-5-methylthiothiophene-2-(3-oxo) propionates, 5a and 5b.
- 社団法人日本薬学会の論文
- 1983-07-25
著者
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千葉 卓男
Pharmaceutical Institute, Tohoku University
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千葉 卓男
Pharmaceutical Institute Tohoku University
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加藤 鉄三
東北大学 薬
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加藤 鉄三
Pharmaceutical Institute Tohoku University
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佐藤 裕利
Pharmaceutical Institute, Tohoku University
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佐藤 裕利
Pharmaceutical Institute Tohoku University
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加藤 鉄三
Pharmaceutical Institute. Tohoku University
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