NOVEL METHODS FOR INTRODUCING A TWO-CARBON UNIT AT EITHER THE 3- OR 4-POSITION OF THE ISOQUINOLONE RING BY MEANS OF PHOTO[2+2]CYCLOADDITION REACTION

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概要

• 論文の詳細を見る

• A novel method is described for introducing a two-carbon unit at either the 3- or 4-position of the 1-isoquinolone ring. The method for the synthesis of the 4-vinyl or 4-ethynyl derivative of isoquinolone consists of 1) photo-addition of the isoquinolone to chloroethylenes and 2) base treatment of the major (head-to-tail) adduct giving the 4-substituted isoquinolones. Similarly, by using 3-methoxyisoquinolone and vinyl acetate in step 1) and an acidic condition in step 2), a formylmethyl group is introduced into the 3-position of the isoquinolone ring.

• 公益社団法人日本薬学会の論文
• 1990-08-25

著者

• 金子 主税

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 金子 主税

  Pharmaceutical Institute Medical Faculty University Of Tokyo

• 千葉 卓男

  Pharmaceutical Institute, Tohoku University

• 千葉 卓男

  Pharmaceutical Institute Tohoku University

• 高田 芳宏

  Pharmaceutical Institute Tohoku University

• 金子 主税

  Pharmaceutical Institute Tohoku University

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