A Novel Synthesis of Revenine and Related Alkaloids by Means of a Photo-rearrangement Reaction of 4-Alkoxy-2-methylquinoline 1-Oxides

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概要

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• Two alkaloids, 1-methyl-4-(3-methylbut-2-enyloxy)-2-quinolone (revenine : IIc) and 4-methoxy-1-methyl-2-quinolone (IIa), were synthesized by means of a photochemical rearrangement reaction of the corresponding 4-alkoxy-2-methylquinoline 1-oxide (Ic and Ia), which were conveniently prepared from 4-chloro-2-methylquinoline 1-oxide (XVII), which in turn is readily obtainable from 2-methylquinoline 1-oxide via the 4-nitrated compound (XVIII). The mechanism of the photo-rearrangement reaction of 4-alkoxy-2-methylquinoline 1-oxides (Ia-d) in methanol is discussed.

• 公益社団法人日本薬学会の論文
• 1979-08-25

著者

• 金子 主税

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 染井 正徳

  Faculty of Parmaceutical Sciences, Kanazawa University

• 内藤 俊彦

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 藤井 春恵

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 金子 主税

  Pharmaceutical Institute Tohoku University

• 橋場 万理美

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 藤井 春恵

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 橋場 万理美

  Faculty Of Pharmaceutical Sciences Kanazawa University

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