The Chemistry of Indoles. XXIV. Syntheses of 3-Indoleacetic Acid and 3-Indoleacetonitrile Having a Halogeno Group and a Carbon Functional Group at the 4-Position
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概要
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Various 4-halogeno-3-indoleacetic acids and -3-indoleacetonitriles were synthesized for the first time by means of the Sandmeyer or Schiemann reaction, demonstrating the versatility of 4-indolediazonium salts in 4-substituted indole chemistry. A practical synthetic method for 4-halogenoindoles was developed by regio-selective thallation-halogenation, and the products were also led to 4-halogeno-3-indoleacetic acids. The first synthesis of 4-formyl-3-indoleacetonitrile is also reported.
- 1985-09-25
著者
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山田 文夫
金沢大薬
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染井 正徳
Faculty of Parmaceutical Sciences, Kanazawa University
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山田 文夫
Faculty of Pharmaceutical Sciences, Kanazawa University
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木津 紀代美
Faculty of Pharmaceutical Sciences, Kanazawa University
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国本 正子
Faculty of Pharmaceutical Sciences, Kanazawa University
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木津 紀代美
Faculty Of Pharmaceutical Sciences Kanazawa University
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国本 正子
Faculty Of Pharmaceutical Sciences Kanazawa University
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