Addition of Molecular Fluorine to Azlactones : General Synthetic Method of erythro-β-Fluorinated α-Amino Acids
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概要
- 論文の詳細を見る
Reaction of molecular fluorine with unsaturated azlactones derived from appropriate aldehydes (or ketones) and benzoylglycine afforded the difluorinated adducts. The reductive amination reaction of the β-fluorinated α-oxoalkanoic acids obtained from the adducts by basic hydrolysis gave erythro-β-fluorinated aliphatic α-amino acids. The same reactions, when applied to methyl 3-phenyl-2-benzoylaminoacrylate, afforded the corresponding aromatic amino acid. Hence, the entire sequence provides a general method for the synthesis of erythro-β-fluorinated α-amino acids.
- 公益社団法人日本薬学会の論文
- 1995-05-15
著者
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佐藤 雅之
静岡県立大学薬学部
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千葉 淳
Pharmaceutical Institute Tohoku University
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金子 主税
東北大学
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金子 主税
Pharmaceutical Institute Medical Faculty University Of Tokyo
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佐藤 雅之
Pharmaceutical Institute, Tohoku University
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豊田 朱見
Pharmaceutical Institute, Tohoku University
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豊田 朱見
東北大学薬学部薬化学教室
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Chiba J
Institute For Materials Research Tohoku University
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