Studies on Ketene and Its Derivatives. CXVIII. Nickel- or Palladium-Catalyzed Reaction of Diketene with Organometallics. Synthesis of 3-Substituted 3-Butenoic Acids

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概要

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• The reaction of diketene (1) with some organometallics was investigated. The reaction of 1 with benzyl Grignard reagents in the presence of nickel (II) chloride afforded 3-benzyl-3-butenoic acids 2a-e. In the presence of dichloro [1,3-bis (diphenylphosphino) propane] nickel, primary alkylmagnesium bromides reacted with 1 to give 3-methylenealkanoic acids 2g-i. (E)-1-Alkenyldiisobutylaluminiums, in the presence of Pd (0)-catalyst, reacted with 1 to give 3-methylene-4-alkenoic acids 5a-c. Similarly, alkynyl-and aryl-zinc chlorides gave 3-methylene-4-alkynoic acids 7a-d and 3-aryl-3-butenoic acids 8a-c, respectively.

• 社団法人日本薬学会の論文
• 1983-12-25

著者

• 佐藤 雅之

  静岡県立大学薬学部

• 佐藤 雅之

  Pharmaceutical Institute, Tohoku University

• 加藤 鐵三

  Central Research Institute Mect Corporation

• 加藤 鐵三

  Pharmaceutical Institute. Tohoku University

• 後藤 浩之

  Pharmaceutical Institute Tohoku University

• 阿部 義仁

  Pharmaceutical Institute, Tohoku University

• 菅原 里恵

  Pharmaceutical Institute, Tohoku University

• 高橋 恵里

  Pharmaceutical Institute, Tohoku University

• 阿部 義仁

  Pharmaceutical Institute Tohoku University

• 高橋 恵里

  Pharmaceutical Institute Tohoku University

• 菅原 里恵

  Pharmaceutical Institute Tohoku University

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