Facile Synthesis of 5α-Fluorocholestan-3-one from 4-Cholesten-3-one via Molecular Fluorine Addition and Reductive Defluorination

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概要

• 論文の詳細を見る

• A facile synthesis of 5α-fluorocholestan-3-one from 4-cholesten-3-one has been accomplished. Direct fluorination of the enone by molecular fluorine gave the cis-vicinal difluoride. Treatment of this adduct with triphenyltin hydride in the presence of azobisisobutyronitrile afforded the title compound.

• 公益社団法人日本薬学会の論文
• 1994-03-15

著者

• 佐藤 雅之

  静岡県立大学薬学部

• 千葉 淳

  Pharmaceutical Institute Tohoku University

• 金子 主税

  東北大学

• 金子 主税

  Pharmaceutical Institute Medical Faculty University Of Tokyo

• 佐藤 雅之

  Pharmaceutical Institute, Tohoku University

• 佐藤 正基

  School Of Pharmaceutical Sciences University Of Shizuoka(present Address):marusa Corporation

• Satoh M

  Showa Pharmaceutical Univ. Tokyo Jpn

• Sato M

  Otsuka Pharmaceutical Co. Ltd. Tokushima Jpn

• 豊田 朱見

  Pharmaceutical Institute, Tohoku University

• 杉田 義昭

  Pharmaceutical Institute, Tohoku University

• 杉田 義昭

  Pharmaceutical Institute Tohoku University

• 豊田 朱見

  東北大学薬学部薬化学教室

• 佐藤 真友美

  Univ. Shizuoka Shizuoka Jpn

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